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Ritonavir or lopinavir/ritonavir drastically maximize plasma concentrations of oxycodone in healthier human volunteers because of inhibition of CYP3A4 and CYP2D6.[fifty eight] Rifampicin greatly cuts down plasma concentrations of oxycodone as a result of solid induction of CYP3A4.Opioids for example oxycodone hydrochloride may possibly influence th